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University of Pretoria, Hillcrest Campus, Pretoria
© 2024 Future Africa | Design and Maintained by ThoughtCorp
Pharmacology and Drug Discovery
I have a background in Animal Physiology and Neuropharmacology that I have acquired after my postgraduate and doctoral studies. I have gained a broad knowledge around neuroscience topic especially on learning, memory and neurodegenerative disorders. My research is motivated by the need to better understand the pathophysiology of neurodegenerative diseases and to find medicinal plants as a novel source of therapeutic leads against this disease. Specifically, my interest included changes in the synaptic transmission (cholinergic, glutamatergic and dopaminergic) leading to memory impairment, molecular dysfunction, neuroinflammation and oxidative stress as pathways involved in aging and neurodegenerative diseases. Nevertheless, I intent to investigate the nootropic and anti-Alzheimer’s actions of medicinal plants looking the molecular insight into therapeutic potential to alleviate Alzheimer’s neuropathology which is burden disease in the world. Presently, I am the Principal Investigator of the International Brain Research Organization “Dietary supplementation with tigernut milk (Cyperus esculentus) attenuates neurotoxic impairment induced by lipopolysaccharide endotoxin via regulation of neuroinflammation, oxidative stress, and apoptotic events». This project is drive by the ambition to fight against neuroinflammation and oxidative related diseases and also challenging the burden of diseases that facing Africa like metabolic disorders with a consequence on central nervous system leading to neurodegenerative disorders using diet supplementation with medicinal and functional food approaches. So far, some of the work already done was to investigate the neuroprotective properties of Carissa edulis a medicinal plant use in Africa on scopolamine-induced memory impairment. Also, we investigated the ameliorative effect of this plant in a rats D-galactose model of Alzheimer’s disease to find out the mechanism of action (under review). The findings of the protective effect of Carissa edulis against L-glutamic acid-induced neurotoxicity in hippocampal neurons by regulating oxidative stress and inflammation have shown that this plant could regulate neuroinflammation and oxidative stress (under review).
University of Pretoria, Hillcrest Campus, Pretoria
© 2024 Future Africa | Design and Maintained by ThoughtCorp